Our group developed a novel amphiphilic metal-organic framework nanosheet membrane with poly(amidoamine) (PAMAM) nanoparticles to serve as cross-linkers. The PAMAM cross-linked nanosheet membrane exhibited an enhanced structural stability in water solution and displayed a remarkable rejection rate for dye molecules. This strategy will certainly shed light on the 2D nanosheet-based molecular sieve applications with high efficacy. This work has been published in Chemical Communications, 2019, 55, 3935-3938.